Gene CYP

There are 2 variants (called allele) of this gene which means that a small section of the CYP1A2 gene has a different nucleotide (building block of nucleic acid) and is marked by A->C substitution at position 734. (1)Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C–>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol. 1999 Apr;47(4):445-9. Available here. (3)Yang A, Palmer AA, De Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology (2010) 211:245-257. Available here. (2)Kohlmeier M. Nutrigenetics: Applying the Science of Personal Nutrition. Academic Press, 2012.
Each of us has two copies of the CYP1A2 gene, one inherited from each parent. These different variants are:
Gene CYP1A2*1A (high activity),
Gene CYP1A2*1F (low activity)

The resulting combination of these gene variants determines if you are a slow or a fast caffeine metabolizer.

Fast caffeine metabolizers have both fast variants – CYP1A2*1A.
In other words, they are homozygous CYP1A2*1A + CYP1A2*1A (fast variant + fast variant).

Slow caffeine metabolizers have at least one slow variant – CYP1A2*1F.
In other words, they are either homozygous CYP1A2*1F + CYP1A2*1F (slow variant + slow variant) or heterozygous CYP1A2*1A + CYP1A2*1F (fast variant + slow variant). (4)Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C–>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol. 1999 Apr;47(4):445-9. Available here. (5)Yang A, Palmer AA, De Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology (2010) 211:245-257. Available here. (6)Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H. Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006 Mar 8;295(10):1135-41. Available here.

Please click here to read more on the topic of the impact of genes on caffeine intake.

References   [ + ]

1. Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C–>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol. 1999 Apr;47(4):445-9. Available here.
2. Kohlmeier M. Nutrigenetics: Applying the Science of Personal Nutrition. Academic Press, 2012.
3. Yang A, Palmer AA, De Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology (2010) 211:245-257. Available here.
4. Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C–>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol. 1999 Apr;47(4):445-9. Available here.
5. Yang A, Palmer AA, De Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology (2010) 211:245-257. Available here.
6. Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H. Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006 Mar 8;295(10):1135-41. Available here.

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